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[13][14][15] GH secretion rates decline exponentially from a peak of about 150 g/kg/day during puberty to about 25 g/kg/day by age 55

Furthermore, neuroprotective and disease-modifying agents, including histone deacetylase 6 (HDAC6) inhibitors and metabolic regulators like metformin, show mechanistic promise but face challenges such as poor solubility, rapid clearance, non-specific distribution, and low brain bioavailability 17,18,19,20